This class engages students in a transdisciplinary conversation about representations of HIV/AIDS: in science writing, journalism, visual art, literature, drama, and popular culture. We believe that scientists and cultural critics can learn valuable lessons from one another, even as they create their own responses to HIV/AIDS. Today, over 30 years since the first scientific reports of HIV/AIDS, the pandemic remains a major health concern throughout the world. But, rays of hope have led to speculation that an AIDS-free generation may be possible. In such a timely moment, it is essential for us to connect across the "two cultures" as we consider the social and scientific implications of HIV/AIDS.